Publications:
2018
Do J-S, Zhong F, Huang AY, van't Hof W, Finney M, Laughlin MJ. Foxp3 expression in induced T regulatory cells derived from human umbilical cord blood vs. adult peripheral blood. Bone Marrow Transplantation 2018. In press.
Zhang M, Kim J, Huang AY. Optimizing tumor microenvironment for cancer immunotherapy: beta-glucan-based nanoparticles. Frontiers in Immunology 2018; 9:341. [Read].
Metheny L, Eid S, Lingas K, Ofir R, Pinzur L, Meyerson H, Lazarus HM, Huang AY. Post-transplant intramuscular injection of PLX-R18 mesenchymal-like adherent stromal cells improves human hematopoietic engraftment in a murine transplant model. Frontiers in Medicine 2018; 5:37. [Read]
Morrow JJ, Mayles I, Funnell APW, Miller TE, Saiakhova A, Lizardo MM, Bartel CF, Kapteijn MY, Hung S, Mendoza A, Dhillon G, Chee DR, Myers JT, Allen F, Gambarotti M, Righi A, DiFeo A, Rubin BP, Huang AY, Meltzer PS, Helman LJ, Picci P, Versteeg HH, Stamatoyannopoulos JA, Khanna C, Scacheri PC. Positively selected enhancer elements endow tumor cells with metastatic competence. Nature Medicine 2018; 24(2): 176-185. [Read]
2017
Dorand RD, Petrosiute A, Huang AY. Multifactorial regulator of tumor PD-L1 response. Transl. Cancer Research 2017. doi: 10.21037/tcr.2017.11.08. [Read]
Allen F, Bobanga I, Rauhe P, Barkauskas D, Teich N, Tong C, Myers J, Huang AY. CCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNgamma. OncoImmunology 2017; 7(3):e1393598. [Read]
Allen F, Myers J, Tong AA, Rauhe P, Nathle J, Eid S, Huang AY. CCL3 enhances antitumor immune priming in the tumor draining lymph node via IFNg with dependency on natural killer cells. Frontiers in Immunology 2017; 8:1390. [Read]
Zhang M, Chun L, Sandoval V, Graor H, Myers J, Nthale J, Rauhe P, Senders Z, Choong K, Huang AY, Kim J. Systemic administration of beta-glucan of 200 kDa modulates melanoma microenvironment and suppresses metastatic cancer. OncoImmunology 2017. https://doi.org/10.1080/2162402X.2017.1387347. [Read]
Wang W, Yu S, Myers J, Wang Y, Xin WW, Alkabri M, Xin AW, Li M, Huang AY, Xin W, Siebel CW, Lazarus HM, Zhou L. Notch2 blockade enhances hematopoietic stem cell mobilization and homing. Haematological 2017; 102: 1785-1795. [Read]
Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW. Live cell visualization of gasdermin D-driven pyroptotic cell death. J Biol Chem 2017; 292(35): 14649-14658 [Read]
Tong AA^, Hashem H^, Eid S, Huang AY. Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing Sarcoma. OncoImmunology 2017; 6(4): e1303586 (^co-first authors). [Read]
Chung J, Ebens CL, Radojcic V, Perkey E, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J. Clinical Investigation 2017; 127(4):1574-1588. [Read]
Shukla S, Myers JT, Wood SE, Gong X, Czapar AE, Commandeur U, Huang AY, Levine A, Steinmetz NF. Plant viral nanoparticules-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers. Biomaterials 2017; 121:15-27. [Read]
Askew D, Pareek T, Eid S, Ganguly S, Tyler AY, Letterio JJ, Cooke KR. Cyclin-dependent kinase 5 (Cdk5) activity is required for generation of allogeneic T cell responses after hematopoietic cell transplantation in mice. Blood 2017; 129(2): 246-256. [Read]
Wilkerson A, Kim J, Huang AY, Zhang M. Nanoparticle systems modulating myeloid-derived suppressor cells for cancer immunotherapy. Current Topics in Medicinal Chemistry 2017; 17(16): 1843-1857. [Read]
2016
Metheny L, Eid S, Lingas K, Reese J, Meyerson H, Tong A, de Lima M, Huang AY. Intra-osseous co-transplantation of CD34-selected umbilical cord blood and mesenchymal stromal cells. Hematology & Medical Oncology 2016. 1(1): 41-45. [Read]
Dorand RD, Nthale J, Myers JT, Barkauskas DS, Avril S, Chirieleison SM, Pareek TK, Abbott DW, Stearns DS, Letterio JJ, Huang AY^, Petrosiute AY^ Cdk5 disruption attenuates tumor PD-L1 expression and promotes anti-tumor immunity. Science 2016. 353(6297): 399-403 (^co-senior authors). [Read]
Allen F^, Tong AA^, Huang AY. Unique transcompartmental bridge: antigen-presenting cells sampling across endothelial and mucosal barriers. Frontiers in Immunology 2016. 7:231. doi: 10.3369/fimmu.2016.00231 (^co-first author). [Read}
Shukla S^, Dorand RD^, Myers JT, Wood SE, Gulati NM, Stewart P, Commandeur U, Huang AY*, Steinmetz NF* Multiple administration of viral nanoparticles alter in vivo behavior - insights from intravital microscopy. ACS Biomaterials Science and Engineering 2016; 2(5): 829-837. (^co-first authors; *co-senior and co-corresponding authors). [Read]
Askew D, Su C, Liou R, Barkauskas D, Dorand RD, Myers JT, Nthale J, Huang AY. Transient surface CCR5 expression by naive CD8+ T cells within inflamed lymph nodes is dependent on HEV interaction and augments helper T-cell dependent memory response. J. Immunol. 2016; 96(9): 3653-3664. [Read]
Wang W, Zimmerman G, Huang X, Myers J, Wang Y, Moreton S, Nthale J, Awadalla A, Beck R, Xin W, Wald D, Huang AY, Zhou L. Abberant Notch signaling in acute lymphoblastic leukemia marrow suppresses osteoblasts and inhibits hematopoietic niche function. Cancer Research 2016; 76(6): 1641-1652. [Read]
Bhaskaran N, Quigley C, Weingerb A, Huang A, Popkin D, Pandiyan P. Transforming growth factor-b1 sustains the survival of FoxP3+ regulatory cells during late phase of oropharyngeal condidiasis infection. Mucosal Immunology 2016; 9:1015-1026. [Read]
2015
Sinyuk M, Alvarado AG, Nesmiyanov P, Shaw J, Mulkearns-Hubert EE, Eurich JT, Hale JS, Bogdanova A, Hitomi M, Maciejewski J, Huang AY, Saunthararajah Y, Lathia JD. Cx25 contributes to leukemia cell communication and chemosensitivity. Oncotarget 2015; 6(31): 31508-31521. [Read]
Delvecchio FR, Vadrucci E, Cavalcanti E, De Santis S, Dale K, Vacca M, Myers J, Allen F, Bianco G, Huang AY, Monsurro V, Santino A, Chieppa M. Polypheol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturation profile. European J. Immunology 2015; 45(9): 2638-2649. [Read]
Omenetti S, Brogi M, Goodman WA, Croniger CM, Eid S, Huang AY, Laffi G, Roskams T, Cominelli F, Pazani M, Pizarro TT. Dysregulated intrahepatic CD4+ T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice. Cellular and Molecular Gastroenterology and Hepatology 2015; 1(4): 406-419. [Read]
Wang W, Yu S, Zimmerman G, Wang Y, Myers J, Yu V, Huang D, Huang X, Shim J, Huang Y, Xin W, Qiao P, Yan M, Xin W, Scadden D, Stanley P, Low JB, Huang AY, Siebel CW, Zhou L. Notch receptor - ligand engagement maintains hematopoietic stem cell quiescence and niche retention. Stem Cells 2015; 33(7): 2280-2293. [Read]
Barkauskas DS, Dorand RD, Myers JT, Evans TA, Barkauskas KJ, Askew D, Purgert R, Huang AY. Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction. Experimental Neurology 2015; 266:74-85 [Read the article].
Owusu-Ansah A, Choi SH, Petrosiute A, Letterio JJ, Huang AY. Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease - a review. Frontiers of Medicine 2015; 9(1): 46-56. [Read]
2014
Dorand RD, Barkauskas DS, Evans TA, Petrosiute A, Huang AY. Comparison of intravital thinned skull and cranial window approaches to study CNS immunobiology in the mouse cortex. Intravital 2014; 3(2): e29728. [Read]
Myers JT, Petrosiute A, Huang AY. Utilization of multiphoton imaging for read-time fate determination of mesenchymal stem cells in an immunocompetent mouse model. J. Stem Cell Res. Ther. 2014; 4(7). pii: 1000217. [Read]
Evans TA, Barkauskas DS, Myers JT, Huang AY. Intravital imaging of dynamic axonal interactions with microglia and macrophages in a mouse dorsal column crush injury. J. Vis. Exp. 2014, (93), e52228. [Read]
Ravikumar M, Snunil S, black J, Barkauskas DS, Huang AY, Miller RH, Selkirk SM, Capadona JR. Blood-derived macrophages dominate over resident microglia in mediating the neuroinflammatory response to implanted intracortical microelectrodes. Biomaterials 2014; 35(28): 8049-8064. [Read]
Cavalcanti E, Vadrucci E, Delvecchio F, Addabbo F, Bettini S, Liou R, Huang AY, Pizzaro TT, Santino A, Chieppa M. Reconstituted oil bodies polyphenol mix administration efficiently suppress dendritic cell inflammatory pathway and acute intestinal inflammation. PLoS One 2014; 9(2): e88898. [Read]
Evans, TA, Barkauskas, DS, Myers J, You, JQ, Hare EG, Ransohoff R, Huang AY*^, Silver J*. High-resolution intravital imaging reveals that blood derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Experimental Neurology 2014; 254:109-120 (Featured as Journal Cover; *Shared Senior Author; ^Communicating PI). [Read]
Scrimieri, F, Askew D, Corn DJ, Eid S, Bobanga ID, Bjelac JA, Tsao ML, Othman YS, Wang SG, Huang AY. Murine Leukemia Virus Envelope Gp70 is a Shared Biomarker for High-sensitivity Detection and Quantification of Murine Tumors. OncoImmunology 2014; 2(11): e26889. [Read]
2013
Bodas P, Huang A, ORiordan MA, Sedor JR, Dell KM. The prevalence of Hypertension and Abnormal Kidney Function in Children with Sickle Cell Disease - a Cross Sectional Review. BMC Nephrol. 2013; 14(1):237. [Read]
Bobanga ID, Petrosiute A, Huang AY. Chemokines as Cancer Vaccine Adjuvants. Vaccines 2013; 1:444-463. [Read]
Barkauskas DS*, Evans TA*, Myers J, Petrosiute A, Silver J, Huang AY. Extravascular CX3CR1+ Cells Extend Intravascular Dendritic Processes intoIntact Central Nervous System Vessel Lumen. Microscopy & Microanalysis 2013; 19(4):778-90. [Read]
Myers J, Barkauskas DS, Huang AY. Dynamic imaging of marrow-resident granulocytes interacting with human mesenchymal stem cell upon systemic lipopolysaccharide challenge. Stem Cell International 2013; 2013:656839. (Highlighted by Global Medical Discovery). [read the article]
2012
Huang AY, Haining WN, Barkauskas DS, Myers J, Petrosiute A, Garrett AP, Singh K, Cooke K, Kean LS. Viewing transplantation immunology through today's lens: new models, new imaging, and new insights. Biol. Blood Marrow Transplant. 2013; 19(1 Suppl): S44-51. [Read]
Mandl JN, Liou R, Klauschen F, Vrisekoop N, Monteiro JP, Yates AJ, Huang AY*, Germain RN*. Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells. Proc. Natl. Acad. Sci. USA 2012; doi/10.1073/pnas. 1211717109 (*co-senior authors). [Read]
Huang AY, Myers JT, Barkauskas D, Howell SJ, Oleinick NL, McCormick TS, Cooper KD, Baron ED, Lam M. Cutaneous penetration of the topically applied photosensitizer Pc4 as detected by intravital 2-photon laser scanning microscopy. Photodiag. Photodyn. Ther. 2012; 9(3): 225-231. [Read]
Liou HLR, Myers JT, Barkauskas DS, Huang AY. Intravital imaging of the mouse popliteal lymph node. J. Vis. Exp. 2012; Feb 8 (60); pii: 3720. doi:10.3791/3720. [Read]
2011
Lathia JD, Gallagher J, Myers JT, Li M, Vasanji A, McLendon RE, Hjelmeland AB, Huang AY, Rich JN. In vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One 2011; 6(9):e24807. Epub 2011 Sep 22. [Read]
2010
Pareek, TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ. Cyclin-dependent kinase 5 activity is required for T cell activation and induciton of experimental autoimmune encephalomyelitis. J. Exp. Med. 2010; 207(11):2507-2519. [Read]
Simmons DP, Canaday DH, Liu Y, Li Q, Huang A, Boom WH, Harding CV. Mycobacgterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9. J. Immunol. 2010; 185(4):2405-2415. [Read]
Myers J, Huang Y, Wei L, Yan Q, Huang A, Zhou L. Fucose-deficient hematopoietic stem cells have decreases self-renewal and aberrant marrow niche occupancy. Transfusion 2010; 50(12):2660-2669. [Read]
Huang AY. Bulging glands? Blame it on B cells. Blood 2010; 115(23):4624- 4626. [Read]
2008
Germain RN, Bajenoff M, Castellino F, Chieppa M, Egen JG, Huang AYC, Ishii M, Koo LY, Qi H. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews 2008; 221:163-181. [Read]
2007
Bajenoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN. Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends Immunol. 2007, 28(8): 346-352. [Read]
Guarda G, Hons M, Soriano SF, Huang AY, Polley R, Martin-Fontecha A, Stein JV, Germain RN, Lanzavecchia A, Sallusto F. L-selectin- CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat. Immunol. 2007, 8(7):743-52. [Read]
Huang AY. Watching Immune Cells in Action. Biology of Blood and Marrow Transplantation 2007, 13:111-114.
2006
Chieppa M, Rescigno M, Huang AY, Germain RN. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TCL engagement. J Exp Med. 2006, 203:2841-52. [Read]
Qi H, Egen JG, Huang AY, Germain RN. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 2006, 312-1672-76. [Read]
Castellino F*, Huang AY*, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 2006, 440:890-95 (*shared first authorship). [Read]
Bajenoff M, Breart B, Huang AY, Qi H, Cazareth J, Braud VM, Germain RN, Glaichenhaus N. Natureal killer cell behavior in lymph nodes revealed by static and real-time imaing. J Exp Med. 2006, 203:619-31. [Read]
2005
Germain RN, Castellino F, Chieppa M, Egen JG, Huang AY, Koo LY, Qi H. An extended vision for dynamic high-resolution intravita immune imaging. Semin Immunol. 2005, 17:431-41. [Read]
2004
Huang AY, Qi H, Germain RN. Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity 2004, 21:331-339. [Read]
[for publications prior to 2004, please visit Dr. Huang's page]