DAVID ASKEW, PhD
Senior Research Associate
Dr. David Askew received his BSc (Hons) degree in Chemistry/Microbiology and a B.A (Gen) in Physical Anthropology from the University of Manitoba in Winnipeg Canada. He then earned his Ph.D. in Microbiology in the laboratory of Dr. Klaus Elgert at Virginia Polytechnic Institute and State University examining the role of macrophage in tumor-induced immunosuppression.
Dr. Askew then joined the laboratory of Dr. William S. Walker at St. Jude’s Children’s Research Hospital in Memphis Tennessee examining the phenotypic and functional heterogeneity of macrophage and microglia.
Upon arrival at Case Western Reserve University, Dr. Askew worked with Dr. Cliff Harding in examining antigen processing and presentation by macrophage and dendritic cells. He followed that work with studying graft-versus host disease, a major complication of stem cell transplant, first in the laboratory of Dr. Anita Giliam (Dermatology) and then with Dr. Ken Cooke (Pediatrics).
For the last few years, Dr. Askew has taken his vast experience in myeloid cell biology to work closely with Dr. Alex Huang to understand the tumor microenvironment with the goal of generating novel immunotherapies against tumors that affect both the pediatric populations and adolescent and young adults (AYA = 14-39) population. By taking advantage of unique animal models and novel technologies that include 2-photon microscopy Dr. Askew is focusing his research on the following:
Understanding the molecular mechanisms of T-cell leukemogensis and CNS metastasis.
Examine the establishment of minimal residual disease of T cell leukemia after stem cell transplant that results in relapse