Welcome to the HUANG LAB
Case Western Reserve University School of Medicine 
Center for Pediatric Immunotherapy
The Angie Fowler AYA Cancer Institute

UH Rainbow Babies & Children's Hospital
University Hospitals Cleveland Medical Center
Cleveland, Ohio USA

Peds Heme/Onc Fellowship
Peds Heme/Onc Fellowship
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RESEARCH PROJECTS
RESEARCH PROJECTS
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PUBLICATIONS
PUBLICATIONS
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PERSONNEL
PERSONNEL
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Alex Y. Huang, M.D., Ph.D.
Principal Investigator
FUTURE SEMINARS & MEETINGS
RECENT PUBLICATIONS

August 8, 2022

Preliminary data gathered by Dr. Sung Hee Choi and a clinical trial concept conceived by Dr. Kristen VanHeyst enabled MedPacto to receive FDA IND approval for an upcoming Phase I/II clinical trial with oral Vactosertib monotherapy in refractory / metastatic Osteosarcoma:

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December 8, 2021

Our lab has just received a 2-year $250,000 grant from the Children's Cancer Research Fund for our work on immune response determinants of cryoablation in rhabdomyosarcoma. Thank you, CCRF!

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December 1, 2021

Congratulations to Dr. Byung-Gyu Kim for being awarded an NCI R03 award for his ongoing work of TGFbeta inhibition in multiple myeloma. Way to go, Byung-Gyu!

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November 28, 2021

Our lab has just received a 1-year $50,000 grant from the Chance for Life for our work in Osteosarcoma.  Thank you, CFL!

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August 31, 2021

Our collaboration with MedPacto in South Korea has resulted in the Orphan Drug Designation from the FDA for Vactosertib, a novel orally bioavailable TGFbeta Type 1 Receptor Kinase. Read the Press Release.

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May 30, 2021

Congratulations to muta abiff for being awarded a 4-year NRSA F31 Diversity Award from the NCI for his work on transcriptional regulation of PDL1 in Medulloblastoma. Congratulations, muta!

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October, 2020

Congratulations to Dr. Mei Zhang whose BG34-200 technology was granted both Rare Disease and Orphan Disease indications by the FDA for its application in adult and pediatric osteosarcoma.

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September, 2020

Congratulations to Dr. Mei Zhang and the Huang Lab for being awarded 2020 Hyundai Hope-on-Wheels Scholar Hope Grant in the amount of $300,000 over 2 years.

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September 16, 2019

Congratulations to Dr. Kristen VanHeyst for being awarded the 2019 Hyundai Hope-on-Wheels Young Investigator Award totaling $200,000 over 2 years.

 

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August 23, 2019

The Huang Lab was awarded the 2019 OutSmarting Osteosarcoma Grant by MIB Agents in the amount of $100,000 to conduct novel immunotherapy research in Osteosarcoma. Dr. Huang will be the keynote speaker at the upcoming FACTOR 2020 meeting in Phoenix, AZ.

 

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Upcoming Seminar Engagement:

  • UH Research & Innovation Day Presentation, November 5, 2021

  • St. Baldrick's Foundation Research Presentation, September 28, 2021

  • Children's Oncology Group OS New Agent Task Force Presentation, September 22, 2021

  • St. Baldrick's Foundation Research Summit, September 13, 2021

  • MIB Agent Update Webinar, September 9, 2021

  • Annual Angie Fowler AYA Cancer Institute Forum / Pediatric Grand Round, UH Rainbow Babies & Children's Hospital, Cleveland, OH, November 5, 2020

  • Mini-retreat, GI Cancer Genetics Scientific Program, Case Comprehensive Cancer Center, Cleveland, OH October 23, 2020.

  • Pediatric Cancer Program Clinical Research Mini-Retreat, CCF, Cleveland OH, October 19, 2020.

  • Sarcoma/Osteosarcoma Collaborations & Comparative Research, 2nd Annual PAWS FOR A CURE Research Symposium, September 30, 2020.

  • Webinar Speaker, OSTEOBites, International zoom webinar series episode V, May 7, 2020.

  • Cancer Center Seminar, UT Southwestern, Dallas TX, May 1, 2020

  • FACTOR 2020, Phoenix AZ, February 28, 2020

  • Grand Round Speaker and Visiting Faculty, Changhua Christian Hospital, Changhua, Taiwan, December 25, 2019.

  • Department of Cancer Biology Seminar, Cleveland Clinic, Cleveland OH, November 22, 2019

  • Pauline Wilson Horner Genetics Symposium, Cleveland OH, September 20, 2019

  • PCRF Gala, Los Angeles CA, September 14, 2019

  • US Lower School SBF Talk, February 22, 2019

  • FACTOR Conference, Miami FL, January 25-26, 2019

  • International Pediatric Neuro-Oncology Symposium, Taipei, Taiwan, December 16, 2018

  • Taipei Medical University Pediatric NeuroOncology Seminar, December 15, 2018

  • CWRU MSTP Dinner Seminar, November 27, 2018.

  • Research Seminar, Department of Pharmacology, CWRU SOM. September 25, 2018

  • The Scientist Expo, Reston VA, September 17-19, 2018

  • Texas Children's Hospital Oncology Seminar, September 13, 2018. Houston, TX

  • Case Comprehensive Cancer Center Annual Retreat, July 27, 2018. Cleveland, OH

  • BIRS Quantitative Immunology, Oaxaca, Mexico, June 24-29, 2018

  • National Cancer Council, New York City, May 21-22, 2018

  • Translating Discoveries to Cure the Kids (TD2), Portland, OR. May 17, 2018

  • Gordon Research Conference, March 25-29, 2018

  • 2nd Pediatric Precision Oncology, Scottsdale, AZ, March 4-7, 2018

  • TRCCC Immunotherapy Conference, Seven Springs, PA, February 14-16, 2018

  • Clinical Translational Science Seminar, CWRU February 12, 2018

New publication release (2017-2022):

2022

VanHeyst KA, Choi SH, Kingsley DT, Huang, AY. Ectopic tumor VCAM-1 expression in cancer metastasis and therapy resistance. Cells. 2022, 11, 3922. (Read)

Nayak L, Sweet DR, Thomas A, Lapping SD, Kalikasingh K, Madera A, Vinayachandran V., Padmanabhan R, Vasudevan NT, Myers JT, Huang AY, Schmaier A, Mackman N, Liao X, Maiseyeu A, Jain MK. A targetable pathway in neutrophils mitigates both arterial and venous thrombosis. Sci. Transl. Med. 2022, 14(660):eabj7465 (Read).

Choi SH, Huang AY, Letterio JJ, Kim BG. Smad4-deficient T cells promote colitis-associated colon cancer via an IFN-g-dependent suppression of 15-hyroxyprostaglandin dehydrogenase. Front. Immunol. 2022, 13:932412 (Read)

Kim BG, Choi SH, Letterio JJ, Song JY, Huang AY. Overexpression of VEGF in the MOPC 315 Plasmacytoma induces tumor immunity in mice. Int. J. Mol. Sci. 2022, 23(9):5235 (Read).

2021

DO JS, Zwick D, Kenyon JD, Zhong F, Askew D, Huang AY, Van't Hof W, Finney M, Laughlin MJ. Mesenchymal stromal cell mitochondrial transfer to human induced T-regulatory cells mediates FOXP3 stability. Sci. Rep. 2021, 11(1):10676 (Read).

Wang L, Yu S, Chen KY, Liu C, Che D, Amadella A, Myers J, Askew D, Chan R, Huang AY, Maillard IP, Huang D, Ivanov I, Xin W, Zhou L. Notch-regulaed dendritic cells restrain inflammation-associated colorectal carcinogenesis. Cancer Immunol. Res. 2021, 9(3): 348-361 (Read).

2020

De Santis S, Verna G, Serino G, Armentano R, Cavalcanti E, Liso M, Dicarlo M, Coletta S, Mastronardi M, Lippolis T, Tafaro A, Santino A, Pinto A, Campiglia P, Huang AY, Cominelli F, Pizzarro TT, Chieppa M. Winnie-APC Min/+ Mice: a spontaneous model of colitis-associated colorectal cancer combining genetics and inflammation. Int. J. Mol. Sci 2020, 21(8):2972 (Read).

2019

Wang SC, Yang KD, Lin CY, Huang AY, Hsiao CC, Lin MT, Tsai YG. Intravenous immunoglobulin therapy enhances suppressive regulatory T cells and decreases innate lymphoid cells in children with immune thrombocytopenia. Peds. Blood & Cancer 2019, e28075 (Read).

Evans TA, Bury LA, Huang AY, Sabo SL. Spatio-temporal dynamics of neocortical presynaptic terminal development using multi-photon imaging of the corpus callosum in vivo. Nature Sci. Report 2019. 9(1): 14028. (Read).

Dorand RD, Benson BL, Huang LF, Petrosiute A, Huang AY. Insights from dynamic neuro-immune imaging on murine immune responses to CNS damage. Front. Neurosci. 2019. 13:737. (Read)

Tong AA*, Forestell B*, Murphy DV, Nair A, Allen F, Myers J, Heim D, Klauschen F, Gopal A, Huang AY^, Mandl J^. Regulatory T cells differ from conventional CD4+ T cells in their recirculatory behavior and lymph node residency times. Immunol. Cell Biol. 2019. doi: 10.1111/imcb.12276. (*co-first authors; ^co-senior authors). [Read]

Gollamudi J, Huang AY, Stavrou EX. Physiological Roles of Leukocytes and Disorders. In: Lazarus H, Schmaier A. (Eds) Concise Guide to Hematology. Springer, Cham. pp 209-224.

2018

Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirleleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Sci. Immunol. 2018. 3(26): pii: eaat2738. [Read].

Qiu H, Zmina PM, Huang AY, Askew D, Bedogni B. Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties. Cancer Lett. 2018. 434:144-151. [Read}

Benson BL, Li L, Myers JT, Dorand RD, Gurkan UA, Huang AY*, Ransohoff RM. Biomimetic post-capillary venule expansions for leukocyte adhesion studies. Nature Scientific Reports 2018. 8:9328. [Read}

Borton AH, Benson BL, Nellson LE, Saunders A, Alaiti MA, Huang AY, Jain MK, Proweller A, Ramirez-Bergeron DL. Aryl hydrocarbone receptor nuclear translocator in vascular smooth muscle cells is required for optimal peripheral perfusion recovery. J Am Heart Assoc 2018. 7(11). pii.e009205. [Read]

Do J-S, Zhong F, Huang AY, van't Hof W, Finney M, Laughlin MJ. Foxp3 expression in induced T regulatory cells derived from human umbilical cord blood vs. adult peripheral blood. Bone Marrow Transplantation 2018. In press.

Huang AY. Cancer Moonshot: Immunotherapy has breathed new life into cancer treatment. Conquer Magazine 2018. 4(1). [Read]

Zhang M, Kim J, Huang AY. Optimizing tumor microenvironment for cancer immunotherapy: beta-glucan-based nanoparticles. Frontiers in Immunology 2018. doi: 10.3389/fimmu.2018.00341. [Read]

Metheny L, Eid S, Lingas K, Ofir R, Pinzur L, Meyerson H, Lazarus HM, Huang AY. Post-transplant intramuscular injection of PLX-R18 mesenchymal-like adherent stromal cells improves human hematopoietic engraftment in a murine transplant model. Frontiers in Medicine 2018. doi: 10.3389/fmed.2018.00037. [Read].

Morrow J, et al. Positively selected enhancer elements endow tumor cells with metastatic competence. Nature Medicine 2018. 24(2): 176-185. doi:10.1038/nm.4475. [Read}

2017

Dorand RD, Petrosiute A, Huang AY. Multifactorial regulator of tumor PD-L1 response. Transl. Cancer Research 2017. doi: 10.21037/tcr.2017.11.08. [Read]

 

Allen F, Bobanga I, Rauhe P, Barkauskas D, Teich N, Tong C, Myers J, Huang AY. CCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNg. OncoImmunology 2017. 7(3): e1393598. [Read]

 

Allen F, Myers J, Tong AA, Rauhe P, Nathle J, Eid S, Huang AY. CCL3 enhances antitumor immune priming in the tumor draining lymph node via IFNg with dependency on natural killer cells. Frontiers in Immunology 2017. 8:1390. [Read]

 

Zhang M, Chun L, Sandoval V, Graor H, Myers J, Nthale J, Rauhe P, Senders Z, Choong K, Huang AY, Kim J. Systemic administration of beta-glucan of 200 kDa modulates melanoma microenvironment and suppresses metastatic cancer. OncoImmunology 2017. 7(2): e1387347. [Read]

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March 18, 2019

Congratulations to Lauren Huang (CWRU 2020) for being awarded 2019 Alex's Lemonade Stand Foundation Pediatric Oncology Student Training (POST) Grant

to study time-dependency of anti-PD-L1

therapy efficacy against PD-L1neg

sarcoma.

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March 8, 2019

Huang Lab is grateful to receive funding support from the I'm Not Done Yet Foundation. The grant will fund a pilot study to obtain pre-clinical data for new immune modulatory therapies for metastatic sarcoma in the pediatric and AYA age groups.

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November 9, 2018

Huang Lab has been awarded a $1.35M 3 year grant from the St. Baldrick's Foundation - Osteosarcoma Collaborative Initiative to create immune-based clinical trials targeting metastatic pulmonary osteosarcoma.

Read Press Release:  #1.   #2.   #3#4.

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September 6, 2018

Congratulations to Dr. Yamilet Huerta for receiving 2018 Hyundai Hope-on-Wheels Young Investigator Award today 

at the handprint ceremony at UH Rainbow Babies & Children's Hospital.

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August 9, 2018

Huang Lab is featured in today's Fox 8 News about the

upcoming Fox Tot on September 8th in support of ALSF. 

Watch the report.

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April 30, 2018

Congratulations to Dr. Frederick Allen for receiving

Honorable Mention at the 2018 Postdoctoral Research

ShowCASE. He will be formally recognized at the

Graduate Awards Ceremony on May 2, 2018.

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April 19, 2018

Congratulations to Dr. Frederick Allen for being

commissioned a Captain in the United States

Army Reserves.

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April 4, 2018

Congratulations to Mohammad Alshebremi for successfully defending his proposal qualify examination.

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March 30, 2018

Congratulations to Dr. Yamilet Huerta for

receiving the 2018 Hyundai Hope-on-Wheels

Young Investigator Award! This is a 2-year,

$200,000 award to begin in December, 2018.

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Yamilet Huerta

December 6, 2017

The Huang Lab has been awarded a 3-year, $150,000 per year Basic Science Research Award from the Pediatric Cancer Research Foundation to

study immunotherapy in pulmonary

metastasis of pediatric and AYA

osteosarcoma. More announcement

to come in January 2018.

Watch the promotional video here.

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December 5-8, 2017

Dr. Huang spoke at the 2nd Global

Congress on AYA Cancer in

Atlanta, GA on Cancer

Immunotherapy in AYACancer. 

Watch the promotional video here.

March 1, 2018

Congratulations to Dr. Yamilet Huerta for

receiving the 2018 St. Baldrick's Foundation

Postdoctoral Fellowship Award in the

amount of $181,600 over 2 years starting in

July 1, 2018.  Read the announcement.

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Yamilet Huerta

January 26, 2018

Read the press release of PCRF Basic Science Award.

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