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Huang Laboratory at Case Western Reserve University School of Medicine

Discovering Immunity in Health & Disease. Finding Cures for Childhood Cancer.

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                                                               This page was last modified on Friday, June 16, 2017 10:36:47 PM

Welcome to the

Huang Lab
Case Western Reserve University School of Medicine 
Principal Investigator

Alex Y. Huang, MD, PhD
Associate Professor of Pediatrics, Pathology, BME and General Medical Sciences

Case Western Reserve University
Angie Fowler AYA Cancer Institute
University Hospitals Cleveland Medical Center
Rainbow Babies & Children's Hospital
Cleveland, Ohio USA

Upcoming Seminar / Conference Engagement:
  • Rowley Scientific Symposium - Alumni Lecture, U. of Chicago, May 19, 2017
  • Pathology Retreat, Albert Einstein College of Medicine, May 29-30, 2017
  • Taipei Medical University, June 30, 2017
  • The Scientist Webinar, July 19th, 2017
  • NANETS Conference, October 19, 2017 (Dr. Petrosiute)
  • Gabrielle Angel Foundation Symposium, November 6-7, 2017
  • Vaccine R&D Conference, Washington DC, November 15-17, 2017
  • 2nd Global AYA Cancer Congress, Atlanta, GA, December 5, 2017
  • BMT-Tandem, Salt Lake City, Utah, February 2018
  • Gordon Conference, March 25, 2018
  • BIRS Quantitative Immunology, Oaxaca, Mexico, June 24-29, 2018

Huang Lab Photos
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Focus of our laboratory:

        Regulation between immune activation and tolerance is crucial in the pathogenesis of cancer. Recent development of intravital 2-photon microscopy allows direct observation of how immune cells traffic and interact with various cells in the tumor micro-environment in real time with single-cell resolution.

       Our laboratory is interested in applying this and other classical immunological techniques to study various aspects of anti-tumor immune responses, immune – host – pathogen interaction, T cell-mediated memory immunity, and chemokine - receptor biology.  Ongoing projects include:
1) Investigation into factors which influence the dynamic recruitment of T cells and their interactions with tumor cells and associated antigen-presenting cells in tumor-associated micro-environment
2) Imaging dynamic interaction between peri-vascular APC and T cells in the CNS during induction of acute experimental autoimmune encephalomyelitis
3) Discovering molecular signaling mechanisms responsible for the regulation of chemokine receptor expression on naive T cells
4) Testing the efficacy of genetically-modified tumor vaccines in the setting of sarcomas and other childhood cancer

5) Developing imaging techniques to interrogate immune cell migration and interactions in tissues such as the bone marrow, lung, GI track and the skin.

6) Cellular and molecular mechanisms of metastasis in osteosarcoma, rhabdomyosarcoma and other common AYA and childhood cancer. 

7) Mechanisms of immune checkpoint regulation in solid tumors.  

8) Molecular mechanisms of T-cell Leukemogensis and CNS metastasis.

9) Exploring NK cell-based immunotherapy strategies against common pediatric and AYA cancers.

The long-term goal of our laboratory is to translate insights gained from basic investigations of in vivo immunity into rationally designed tumor vaccine and immunotherapeutic clinical trials, with a particular emphasis in the areas of pediatric sarcomas and other solid tumors in the pediatric and adolescent & young adult (AYA) populations.  

Recent Publications: (My NCBI)


Tong AA^, Hashem H^, Eid S, Huang AY. Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing Sarcoma. OncoImmunology 2017; doi: 10.1080/216240X.2017.1303586(co-first authors)

Chung J, Ebens CL, Radojcic V, Perkey E, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I. Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands. J. Clinical Investigation 2017; 127(4):1574-1588.


Shukla S, Myers JT, Wood SE, Gong X, Czapar AE, Commandeur U, Huang AY, Levine A, Steinmetz NF. Plant viral nanoparticules-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers. Biomaterials 2016; 121:15-27.

Askew D, Pareek T, Eid S, Ganguly S, Tyler AY, Letterio JJ, Cooke KR. Cyclin-dependent kinase 5 (Cdk5) activity is required for generation of allogeneic T cell responses after hematopoietic cell transplantation in mice. Blood 2016; 129(2): 246-256.

Metheny L, Eid S, Lingas K, Reese J, Meyerson H, Tong A, de Lima M, Huang AY. Intra-osseous co-transplantation of CD34-selected umbilical cord blood and mesenchymal stromal cells. Hematology & Medical Oncology 2016. 1(1): 41-45.

Dorand RD, Nthale J, Myers JT, Barkauskas DS, Avril S, Chirieleison SM, Pareek TK, Abbott DW, Stearns DS, Letterio JJ, Huang AY^, Petrosiute AY^ Cdk5 disruption attenuates tumor PD-L1 expression and promotes anti-tumor immunity. Science 2016. 353(6297): 399-403 (^co-senior authors).

Wilkerson A, Kim J, Huang AY, Zhang M. Nanoparticle systems modulating myeloid-derived suppressor cells for cancer immunotherapy. Current Topics in Medicinal Chemistry 2016. Nov 22 [Epub ahead of print].

Allen F^, Tong AA^, Huang AY. Unique transcompartmental bridge: antigen-presenting cells sampling across endothelial and mucosal barriers. Frontiers in Immunology 2016. 7:231. doi: 10.3369/fimmu.2016.00231 (^co-first author)

Shukla S^, Dorand RD^, Myers JT, Wood SE, Gulati NM, Stewart P, Commandeur U, Huang AY*, Steinmetz NF* Multiple administration of viral nanoparticles alter in vivo behavior - insights from intravital microscopy. ACS Biomaterials Science and Engineering 2016; 2(5): 829-837. (^co-first authors; *co-senior and co-corresponding authors)

Askew D, Su C, Liou R, Barkauskas D, Dorand RD, Myers JT, Nthale J, Huang AY. Transient surface CCR5 expression by naive CD8+ T cells within inflamed lymph nodes is dependent on HEV interaction and augments helper T-cell dependent memory response. J. Immunol. 2016; 96(9): 3653-3664.

Wang W, Zimmerman G, Huang X, Myers J, Wang Y, Moreton S, Nthale J, Awadalla A, Beck R, Xin W,  Wald D, Huang AY, Zhou L. Abberant Notch signaling in acute lymphoblastic leukemia marrow suppresses osteoblasts and inhibits hematopietic niche function. Cancer Research. 2016; 76(6): 1641-1652.


Bhaskaran N, Quigley C, Weingerb A, Huang A, Popkin D, Pandiyan P. Transforming growth factor-b1 sustains the survival of FoxP3+ regulatory cells during late phase of oropharyngeal condidiasis infection. Mucosal Immunology 2015; Doi: 10.1038/mi.2015.115 [Epub ahead of print].

Sinyuk M, Alvarado AG, Nesmiyanov P, Shaw J, Mulkearns-Hubert EE, Eurich JT, Hale JS, Bogdanova A, Hitomi M, Maciejewski J, Huang AY, Saunthararajah Y, Lathia JD. Cx25 contributes to leukemia cell communication and chemosensitivity. Oncotarget 2015; 6(31): 31508-31521.

Delvecchio FR, Vadrucci E, Cavalcanti E, De Santis S, Dale K, Vacca M, Myers J, Allen F, Bianco G, Huang AY, Monsurro V, Santino A, Chieppa M. Polypheol administration impairs T-cell proliferation by imprinting a distinct dendritic cell maturation profile. European J. Immunology 2015; 45(9): 2638-2649.

Omenetti S, Brogi M, Goodman WA, Croniger CM, Eid S, Huang AY, Laffi G, Roskams T, Cominelli F, Pazani M, Pizarro TT. Dysregulated intrahepatic CD4+ T-cell activation drives liver inflammation in ileitis-prone SAMP1/YitFc mice. Cellular and Molecular Gastroenterology and Hepatology 2015; 1(4): 406-419.

Wang W, Yu S, Zimmerman G, Wang Y, Myers J, Yu V, Huang D, Huang X, Shim J, Huang Y, Xin W, Qiao P, Yan M, Xin W, Scadden D, Stanley P, Low JB, Huang AY, Siebel CW, Zhou L. Notch receptor - ligand engagement maintains hematopoietic stem cell quiescence and niche retention. Stem Cells 2015; 33(7): 2280-2293.

Barkauskas DS, Dorand RD, Myers JT, Evans TA, Barkauskas KJ, Askew D, Purgert R, Huang AY. Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction. Experimental Neurology 2015; 266:74-85
(Read the article).

Owusu-Ansah A, Choi SH, Petrosiute A, Letterio JJ, Huang AY. Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease - a review. Frontiers of Medicine 2015; 9(1): 46-56.

Dorand RD, Barkauskas DS, Evans TA, Petrosiute A, Huang AY. Comparison of intravital thinned skull and cranial window approaches to study CNS immunobiology in the mouse cortex. Intravital 2014; 3(2): e29728.

Evans TA, Barkauskas DS, Myers JT, Huang AY. Intravital imaging of dynamic axonal interactions with microglia and macrophages in a mouse dorsal column crush injury. J. Vis. Exp. 2014, (93), e52228.

Ravikumar M, Snunil S, black J, Barkauskas DS, Huang AY, Miller RH, Selkirk SM, Capadona JR. Blood-derived macrophages dominate over resident microglia in mediating the neuroinflammatory response to implanted intracortical microelectrodes. Biomaterials. 2014; 35(28): 8049-8064.

Cavalcanti E, Vadrucci E, Delvecchio F, Addabbo F, Bettini S, Liou R, Huang AY, Pizzaro TT, Santino A, Chieppa M. Reconstituted oil bodies polyphenol mix administration efficiently suppress dendritic cell inflammatory pathway and acute intestinal inflammation. PLoS One 2014; 9(2): e88898.

Evans, TA, Barkauskas, DS, Myers J, You, JQ, Hare EG, Ransohoff R, Huang AY*^, Silver J*. High-resolution intravital imaging reveals that blood derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury. Experimental Neurology 2014; 254:109-120 (Featured as Journal Cover; *Shared Senior Author; ^Communicating PI).

Scrimieri, F, Askew D, Corn DJ, Eid S, Bobanga ID, Bjelac JA, Tsao ML, Othman YS, Wang SG, Huang AY. Murine Leukemia Virus Envelope Gp70 is a Shared Biomarker for High-sensitivity Detection and Quantification of Murine Tumors. OncoImmunology 2014; 2(11): e26889.

Bodas P, Huang A, ORiordan MA, Sedor JR, Dell KM. The prevalence of Hypertension and Abnormal Kidney Function in Children with Sickle Cell Disease - a Cross Sectional Review. BMC Nephrol. 2013; 14(1):237.

Bobanga ID, Petrosiute A, Huang AY. Chemokines as Cancer Vaccine Adjuvants. Vaccines 2013; 1:444-463.

Barkauskas DS*, Evans TA*, Myers J, Petrosiute A, Silver J, Huang AY. Extravascular CX3CR1+ Cells Extend Intravascular Dendritic Processes intoIntact Central Nervous System Vessel Lumen. Microscopy & Microanalysis 2013; 19(4):778-90.

Myers J, Barkauskas DS, Huang AY. Dynamic imaging of marrow-resident granulocytes interacting with human mesenchymal stem cell upon systemic lipopolysaccharide challenge. Stem Cell International. 2013; 2013:656839.
(Highlighted by Global Medical Discovery... read the article)

Huang AY, Haining WN, Barkauskas DS, Myers J, Petrosiute A, Garrett AP, Singh K, Cooke K, Kean LS. Viewing transplantation immunology through today's lens: new models, new imaging, and new insights. Biol. Blood Marrow Transplant. 2013; 19(1 Suppl): S44-51.

Mandl JN, Liou R, Klauschen F, Vrisekoop N, Monteiro JP, Yates AJ, Huang AY*, Germain RN*. Quantification of lymph node transit times reveals differences in antigen surveillance strategies of naive CD4+ and CD8+ T cells Proc. Natl. Acad. Sci. USA 2012; doi/10.1073/pnas. 1211717109 (*co-senior authors)

g AY, Myers JT, Barkauskas D, Howell SJ, Oleinick NL, McCormick TS, Cooper KD, Baron ED, Lam M. Cutaneous penetration of the topically applied photosensitizer Pc4 as detected by intravital 2-photon laser scanning microscopy. Photodiag. Photodyn. Ther. 2012; 9(3): 225-231.

Liou HLR
, Myers JT, Barkauskas DS, Huang AY. Intravital imaging of the mouse popliteal lymph node. J. Vis. Exp. 2012; Feb 8 (60); pii: 3720. doi:10.3791/3720.


Lathia JD, Gallagher J, Myers JT, Li M, Vasanji A, McLendon RE, Hjelmeland AB, Huang AY, Rich JN. In vivo evidence for tumor propagation by glioblastoma cancer stem cells. PLoS One. 2011; 6(9):e24807. Epub 2011 Sep 22.
Pareek, TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ. Cyclin-dependent kinase 5 activity is required for T cell activation and induciton of experimental autoimmune encephalomyelitis. J. Exp. Med. 2010; 207(11):2507-2519.
Simmons DP, Canaday DH, Liu Y, Li Q, Huang A, Boom WH, Harding CV. Mycobacgterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9. J. Immunol. 2010; 185(4):2405-2415.
Myers J, Huang Y, Wei L, Yan Q, Huang A, Zhou L. Fucose-deficient hematopoietic stem cells have decreases self-renewal and aberrant marrow niche occupancy. Transfusion 2010; 50(12):2660-2669.
Huang AY. Bulging glands? Blame it on B cells. Blood. 2010; 115(23):4624- 4626.
Germain RN, Bajenoff M, Castellino F, Chieppa M, Egen JG, Huang AYC, Ishii M, Koo LY, Qi H. Making friends in out-of-the-way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging. Immunological Reviews 2008; 221:163-181

Bajenoff M, Egen JG, Qi H, Huang AY, Castellino F, Germain RN. Highways, byways and breadcrumbs: directing lymphocyte traffic in the lymph node. Trends Immunol. 2007, 28(8): 346-352.

Guarda G, Hons M, Soriano SF, Huang AY, Polley R, Martin-Fontecha A, Stein JV, Germain RN, Lanzavecchia A, Sallusto F. L-selectin- CCR7- effector and memory CD8+ T cells enter reactive lymph nodes and kill dendritic cells. Nat. Immunol. 2007, 8(7):743-52.
Huang AY. Watching Immune Cells in Action. Biology of Blood and Marrow Transplantation. 2007, 13:111-114.
Chieppa M, Rescigno M, Huang AY, Germain RN. Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TCL engagement. J Exp Med. 2006, 203:2841-52.
Qi H, Egen JG, Huang AY, Germain RN. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 2006, 312-1672-76.
Castellino F*, Huang AY*, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 2006, 440:890-95 (*shared first authorship).
Bajenoff M, Breart B, Huang AY, Qi H, Cazareth J, Braud VM, Germain RN, Glaichenhaus N. Natureal killer cell behavior in lymph nodes revealed by static and real-time imaing. J Exp Med. 2006, 203:619-31.
Germain RN, Castellino F, Chieppa M, Egen JG, Huang AY, Koo LY, Qi H. An extended vision for dynamic high-resolution intravita immune imaging. Semin Immunol. 2005, 17:431-41.
Huang AY, Qi H, Germain RN. Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues. Immunity 2004, 21:331-339.
[for a complete list of publications, please see ABOUT US page]


Huang Lab NEWS...

June 2017

The Huang Lab & Petrosiute Lab have been awarded NCI R21 grant to study the effect of adhesion molecules in osteosarcoma pulmonary metastasis. Congratulations!

June 13, 2017

Congratulations to Alex Tong for successfully defending his public and private thesis defense. Well done, Dr. Alex Tong!

May 22, 2017

Dr. Huang was recognized for receiving 2017 John S. Diekhoff Award in Graduate Mentoring at the Graduate School Commencement Ceremony. He is only the 2nd faculty from a clinical department at CWRU SOM to be recognized since 1978.

Watch the 2017 Commencement Ceremony here.

May 19, 2017

Dr. Huang was invited as a speaker for the 5th Annual Janet & Don Rowley Scientific Symposium at the U. Chicago

May 2017

Huang Lab was featured as cover of 2017 University Hospitals Annual Report

May 12, 2017


Huang lab members were well represented at the 2017 AAI Annual Meeting in Washington, DC. Fred Allen gave an oral presentation at Block Symposium. Alex Tong and Bryan Benson presented their studies in poster sessions.

May 3, 2017
Dr. Huang received the 2017 John S. Diekhoff Award in Graduate Mentoring at CWRU Graduate Studies Award Ceremony at Tinkham Veale. Dr. Dixon Dorand also received his Doctoral Excellence Award in Pathology at the same ceremony.

April 27, 2017

President Snyder and Provost Baeslack paid a surprise visit to present the 2017 John S. Diekhoff Award for Graduate Mentoring. The award will be formally presented during the Graudate School Award Ceremony on May 3rd and the Graduate School Commencement on May 21, 2017.

April 7, 2017

Congratulations to Dr. Dixon Dorand for being awarded 2017 CWRU School of Medicine's Doctoral Excellence in Research Award in Pathology. Well done, Dixon!

April 7, 2017

Former member of the Huang Lab, Dr. Jennifer Tsai, was featured in the St. Baldrick's Foundation article on the impact of SBF Summer Fellowship Program. Dr. Tsai is currently a first year Pediatric Heme/Onc Fellow at Stanford. Read the article.

March 31, 2017

Huang Lab was featured in this IdeaStream / PBS / WVIZ
broadcast on Immunotherapy explained in the style of Star Wars.

March 22, 2017

Huang Lab was selected by the Cleveland Award Program as the recipient of the 2017 Best of Cleveland Award in the Research category. Read the press release.

March 10, 2017

Huang Lab participated in yet another year of Head Shaving Event at UH Rainbow Babies & Children's Hospital. Team Rainbow has raised $8900+ and was featured in the following Sunday's Plain Dealer and Cleveland Brown's official website:

February 1, 2017

January 2017

Article about the Huang Lab involvement in Cancer Moonshot Initiative

January 13, 2017

Congratulations to Dr. Anant Vatsayan, who has just been accepted to Pediatric Bone Marrow Transplant Fellowship at MSKCC starting July 1, 2017. We are so proud of you, Anant!

January 3, 2017

Huang Lab is a participant of the CWRU Center for Multimodal Evaluation of Engineered Cartilage(funded by NIBIB P41 in July 2016). 

December 18, 2016

Dr. Agen Petrosiute's recent publication in Science (Dorand et al. Science 2016) was featured in an article by St. Baldrick's Foundation.

December 17, 2016

Read Dr. Huang's commentary on Pediatric Immunotherapy upon the release of "Rogue One: The Star Wars Story"

December 14, 2016

First webinar to feature pediatric cancer immunotherapy by Cancer Research Institute, given by Dr. Alex Huang. Click on the image to listen to the complete recording:

December 6, 2016

The Harrington Discovery Institute selected Dr. Huang as a 2016 Harrington Fellow, part of the Harrington Project for Discovery & Development / Harrington Discovery Institute at University Hospitals. The recognition is accompanied by a $75000 / year x 2 year unrestricted funding.

December 5, 2016

Congratulations to Bryan Benson for being awarded a 2-year F31 Grant from NINDS on his ongoing project, "Using Microfluidics to Investigate Mechanisms of Leukocyte Intravascular Crawling." Well done, Bryan!

November 18, 2016

Congratulations to Henry-Robert Thomas, 2016 CWRU HLB Summer Fellow, for winning First Place Poster Presentation at the University of Illinois at Chicago College of Medicine Research Forum Cancer Center Category, and Honorable Mention Poster Presentation in the Medical Student category. Henry thanks the tremendous mentorship of Dr. Agne Petrosiute, Fred Allen and Alex Tong, as well as help from Alice Wu, our SEA summer student from Solon High School.

October 8, 2016

Dr. Huang co-chaired the St. Baldrick's Foundation 2017 Research Summit in New York.

September 23, 2016

Congratulations to Alex Tong for being awarded best oral presenter at the Immunology Training Program Annual Retreat. Great job, AT!


September 12, 2016

Congratulations to the Huang Lab for being recognized by CWRU for its diversity nature as the inaugural recipient of Faculty Diversity Award.

August 26, 2016

Huang Lab will once again participate in Alex's Lemonade Stand Foundation September Million Mile Run / Walk / Bike event for the 4th year in a row. Please join our team, "Run, Alex! Run!" and help log in the miles by running, walking or biking during the month of September. Equally importantly, help us raise $$ to fund pediatric research. Every $ raised through team, "Run, Alex! Run!" will come back as $2 direct cost to cover expenses for our research program. Please consider joining us!

July 27, 2016

We had a fantastic time hosting 9 summer students among Huang / Petrosiute / Avril labs this summer. The students all did a wonderful job, including outstanding oral presentations at the lab meeting today. Thanks to their immediate supervisors for all the mentoring and help!

July 22, 2016

A study detailing a critical role of Cdk5 in modulating PD-L1 expression by medulloblastoma and other tumors in response to interferon-gamma has just been published in Science. Congratulations, Dr. Dorand and Dr. Petrosiute.

Read the article abstract.
Read the press release.

July, 2016

We welcome summer students (medical school, undergrad, postbac, high school) to Huang Lab.

From left to right: Edvinas Vaicikauskas, Daniel Kingsley, Benjamin Reinthal, Alice Wu, Gabby Kolk, Henry Thomas, Dre Jett, Nimisha Swali, Candilianne Serrano Zayas.

Not pictured: Daniel Murphy

May 24, 2016

Huang Lab is featured on the newest LabTV channel, UH Rainbow Babies & Children's Hospital. Watch it here.

May 14, 2016

Festivities at the Graduation Ceremony for Dixon Dorand (PhD) and Teresa Evans (MD-PhD). Congratulations!


May 13, 2016

congratulations to Laura Menocal for being named 2016 CWRU PREP Scholar of the Year. Terrific news and
congratulations, Laura.

April 27, 2016

Dr. Huang has been named a member of the Cancer Immunology & Prevention Working Group of the Blue Ribbon Panel (BRP), part of the National Cancer Advisory Board (NCAB), charged with providing expert advice on the vision, proposed scientific goals, and implementation of the National Cancer Moonshot that was announced by President Barack Obama in late January 2016 and led by Vice President Joe Biden.

April 26, 2016

Congratulations to Dixon, for having successfully defended his PhD Thesis. We are very proud of you, Dixon.


March 18, 2016

Team Rainbow, led by the Huang Lab, participated in the annual St. Baldrick's Foundation Head Shaving Event for the 8th year in a row. Sir Alex Huang knighted two members of the Huang Lab, Dr. David Askew and Mr. Jay Myers, who now officially belong to the exclusive Knights of the Bald Table. Team Rainbow has raised $27,876 (over our initial goal of $20K), and UH Rainbow has raised $92,581 as of today.

Job well done everyone!

March 18, 2016

Congratulations to alumni of the Huang Lab, Dr. Teresa Evans and Dr. Chuck Su on their successful Match. Dr. Evans will be heading to Pediatric Residency Research Track at Stanford, and Dr. Su will be joining Orthopedics Residency at CWRU / UH Case Medical Center. Job well done, Teresa and Chuck!

January 14, 2016

Dr. Agne Petrosiute and Dr. Alex Huang have been awarded as co-PIs of a Cancer Center P30 Pilot Grant to study molecular mechanisms of PD-L1 expression control by tumor cells during immune surveillance.

Earlier this past Fall we were visited by members of the Samuel Szabo Foundation who generously donated $15,000 to support research activities in the Huang Lab and the efforts of Dr. Anant Vatsayan, the Samuel Szabo Fellow.

Thank you, Supporters of the Samuel Szabo Foundation!

December, 2015

Dr. Alex Huang has been named a member of the St. Baldrick's Foundation Scientific Advisory Committee.

November, 2015

Congratulations to Alex Tong for being awarded best poster presentation award at the annual Department of Pathology Scientific Retreat, CWRU School of Medicine. 

November, 2015

Congratulations to Dixon Dorand for being named a recipient of the 2016 Keystone Symposia Future of Science Fund Scholarship. This award provides travel funds to attend the upcoming Keystone Tumor Immunology meeting at Whistler, British Columbia. Congratulations, Dixon.

September 17, 2015

Our 2015 SBF Summer Fellow, Daniel Kingsley, shared his personal experience as a cancer survivor and a pediatric cancer researcher in the most recent issue of ACCC Oncology. We are proud of you, Dan. Read this article.

September 15, 2015

The Huang Lab received a $250,000 grant over 2 years from the Hyundai Hope-on-Wheels Program to tackle metastatic osteosarcoma. A hand print ceremony was held in the UH Atrium this morning. Read the post.

September, 2015

For the 3rd year in a row, the Huang Lab is participating in Alex's Lemonade Stand Foundation's Million Mile Run, Walk or Ride! fundraiser. Please join team, "Run, Alex! Run!" and help us raise money for childhood cancer research. Every $1.00 donated to Run, Alex! Run! will come back directly to UH Rainbow Babies as $2.00 to fund local research here in Cleveland!

July 22, 2015

The Huang Lab welcomes Laura Menocal to the lab. Laura is a CWRU PREP Scholar who will be in the lab for 1 year.

July, 2015

Congratulations to Alex Tong for winning the coveted "Data Blitz" during the MSTP Summer Retreat!

June 23, 2015

Congratulations to Dr. Agne Petrosiute for being awarded a highly competitive 3-year, $330,000 St. Baldrick's Foundation Scholar Award for her work on the biology of Cdk5 in tumor immune evasion. A special recognition, "Rebecca Allison Meyer Fund for Pediatric Cancer Research St. Baldrick's Scholar" was bestowed upon Dr. Petrosiute by the St. Baldrick's Foundation for receiving this award.  Fantastic work, Dr. Petrosiute!

The Huang Lab was also awarded a $100,000 St. Baldrick's Research Award. This is a joint grant with Dr. John Letterio at the Angie Fowler AYA Cancer Institute for our study of Cdk5 in Notch-induced T cell leukemia.

May 28, 2015

The Huang Lab has just been awarded a 2-year, $250,000 Innovator Award from Alex's Lemonade Stand Foundation. Congratulations everyone and thank you to the ALSF for their investment into the development of effective immunotherapy for metastatic sarcoma.

May 12, 2015

Congratulations to Dixon Dorand for being awarded a 3-year F31 Fellowship from NCI. Great job, Dixon.

May 9, 2015

Congratulations to Alex Tong for being chosen for an oral presentation at the 2015 AAI Meeting in New Orleans, LA. Also congratulations to Dixon Dorand for being awarded a travel award to the AAI. Alex Tong, Dixon and Fred Allen all presented posters at the AAI. Great job, guys.

May 7, 2015

UH Rainbow / Angie Fowler AYA Cancer Institute had a strong showing at the 2015 ASPHO meeting in Phoenix, AZ with multiple poster presentation and 2 platform presentations. 

May 6, 2015

Congratulations to Hasan Hashem for a job well-done for his platform presentation at the PBMTC / ASPHO Tandem Meeting in Phoenix.

May 1, 2015

The Huang Lab has been awarded a 2-year, $275K R21 grant by the National Cancer Institute, "Cdk5 signaling in ICN1-induced T Cell Leukemogenesis". This will be conducted as a collaborative project with the Letterio Lab at the Angie Fowler AYA Cancer Institute.

April 22, 2015

Congratulations to Daniel Kingsley for being awarded the 2015 St. Baldrick's Foundation Summer Research Fellowship. Read this great interview article on Dan.

April 13, 2015

The Huang Lab has been awarded for the third year from the Steven G. AYA Cancer Research Fund in the amount of $25,500 to support the research of 3 investigators: Dr. David Askew, PhD, Elise Rispoli, and Robert Purgert. Congratulations.

April 4, 2015

The Huang Lab has been awarded a two-year, $250,000 Scholar Grant from 2015 Hyundai Hope-on-Wheels Program. The Huang Lab received 1 of 36 awards in the US, and the only awardee in Ohio.

March 13, 2015

Jenn and Brian of the Keira Kilbane Foundation were present at the annual St. Baldrick's Foundation Head Shaving event at University Hospital
s Rainbow Babies & Children's Hospital to perform the "Knighting Ceremony" for induction of Alex Huang into the "Knights of the Bald Table." Dr. Huang will henceforth be known as Sir Alex. 

The Keira Kilbane Foundation has also established a "Keira Kilbane Cancer Discovery Fund" at UH Rainbow to support Angie Fowler AYA Ca
ncer Institute Reseach. Donations can be made to UH Rainbow Babies towards this fund. Check out the new Foundation Website and Facebook page.

March 13, 2015

Huang Lab participated again in this year's St. Baldrick's Foundation Head Shaving Event. Dr. Huang was inducted as Knight of the Bald Table for shaving his head 7th year in a row. We had >100 shavee, 31 female shavee, 13 nurses, and an 88-year-old shavee. $100,000+ and climbing:  Watch the video.

Donate to:
UH Site
Team Rainbow
Alex Huang

March 5, 2015

The Huang Lab has received a 4th year of Summer Fellowship Grant from the St. Baldrick's Foundation. The recipient of the summer fellowship award is Daniel Kingsley from Kent State University.

March 3, 2015

Congratulations to Dixon Dorand, Alex Tong and Bryan Benson for receiving Poster Presentation Awards at the CWRU MSTP Winter Retreat on March 3, 2015. Good job, everyone!

February 10, 2015

Congratulations to Dr. Hasan Hashem for receiving a young investigator travel award and presentation at the PBMTC / ASPHO meeting in Pheonix, AZ in May 2015.

Dawn of a new era in cancer therapy: Immunotherapy

December 12, 2014

Congratulations to Dr. Agne Petrosiute
for receiving a $10,000 Core Utilization Grant from CTSC for her project to identify targets of Cdk5 enzymatic activity in CNS tumors.

December 4, 2014

The Huang Lab is very grateful to receive another year of funding support from the Pediatric Cancer Research Foundation (PCRF) in the amount of $25,000 to for our ongoing research into pulmonary metastasis of Osteosarcoma.

December 4, 2014

We are honored to help launch the Keira Kilbane Foundation. Please support this most worthy cause.

November 6, 2014

The Huang Lab has been awarde
d one of 20 infrastructure grants by the St. Baldrick's Foundation in the amount of $50,000. This fund supports personnel in the lab charged with building a patient-derived xenograft farm for Pediatric and AYA cancer specimens in an effort to expand our research in immunotherapy for childhood and AYA cancers. Read CWRU News Release.


ReadAgne's blog on Medulloblastoma on St. Baldrick's Foundation website.

September 23, 2014

Congratulations to Dr. Agne Petrosiute for receiving a $250,000 Hyundai Hope-on-Wheels Hope Grant at a Hand Print Ceremony today at UH Atrium. Dr. Petrosiute also attended a Pediatric Oncology Think Tank Summit at Washington D.C. last week. Congratulations, Agne!

(Watch local news coverage of the event)


September 15, 2014

Congratulations to Fred Allen for being awarded a 3-year NRSA F31 Fellowship Award from NCI/NIH on his proposed study, "Inflammatory chemokine CCL3 in the tumor microenvironment leads to enhanced antitutmor immune development in the draining lymph node." Way to go, Fred!

September 13, 2014

We are grateful to receive a scholarship support for fellow-initiated research in childhood cancer from the Samuel Szabo Foundation. Please help support this great Foundation. We look forward to developing a great relationship with the Foundation and to help furthering the great cause! The recipient of the Fellowship Grant will be announced soon.

September 12, 2014

We are almost halfway through our September Fundraising for Childhood Cancer through Alex's Lemonade Stand Foundation's Million Mile R
un Initiative. Team "Run, Alex! Run!" is raising the miles and dollars to stand in solidarity with children and families battling childhood and adolescent cancer. Every dollar donated through "Run, Alex! Run!" team will come back doubled directly to Rainbow Pediatric Research, and every mile run, walked or biked will be matched by a $1 donation from Northwestern Mutual. Starting mid-night September 15 through 6am September 16 (30 hours), every dollar donated to team, "Run, Alex! Run!" will be matched $ for $ by Volvo. The funds will be raised to help establish the Keira Kilbane Research Fund in memory of Princess Keira.

August 21, 2014

Congratulations to Dr. Leland Metheny for receiving a $10,000 Core Utilization Grant from CTSC for his project "Pre-Clinical Model Using Pluristem Administration for Delayed Engraftment after Heatopoietic Cell Transplant." This project is co-mentored by Dr. Hillard Lazarus.

August, 2014

The Huang Lab is once again getting ready for the Million Mile Run (MMR) in support of Alex's Lemonade Stand Foundation. In September, team "Run, Alex! Run!" will be raising awareness and research funds in support of childhood cancer research in partnership with the Alex's Lemonade Stand Foundation. Every $$ you give through Team "Run, Alex! Run!" will double (2X) and come back directly to the Huang Lab. You can: 1) join the team (; 2) Text to donate $10 (text "lemonade E1116964" to 89544); 3) Participate in our 5K Run on Saturday, September 6 at 10am on MLK Drive near University Circle; 4) Have fun at the Scavenger Hunt, Saturday September 27 at 3pm-6pm; 5) Join a Raffle Drawing on Saturday September 27 with a First Prize a iPad mini.

Click here for more information! We are counting on your support!

August 12, 2014

Read an article featured in St. Baldrick's FoundationNewsletter as Dr. Petrosiute discusses research on immunotherapy for Medulloblastoma.

July 1, 2014

Another academic year has come and gone.... and we say our fond good-byes to Dr. Francesca Scrimieri, Dr. Iuli Bobaga, Dr. Teresa Evans and Matt Tsao. We will miss all of you. Come back to visit often!

June 24, 2014

Congratulations to Dr. Agne Petrosiute for her promotion to the rank of Assistant Professor in the Department of Pediatrics at Case Western Reserve University.

June 11, 2014

The entire Huang Lab family was recognized by the University Hospitals for their many accomplishments through the dedication of the endowed Theresia G. & Stuart F. Kline Family Foundation Chair of Pediatric Oncology to Dr. Huang.


May, 2014

Congratulations to Leland Metheny, MD for winning the Best Abstract Award  at the Department of Medicine Science Day, CWRU / UH.

May, 2014

Congratulations to Francesca Scrimieri for being named a finalist of the 2014 Paola Campese Award for Research in Cancer, Italian Scientists and Scholars of North American Foundation. Winner will be announced later in the fall.

May 13, 2014

Congratulations to Iuliana Bobanga, MD for wining first place oral presentation at the Cleveland Surgical Society meeting.

May 8, 2014

Congratulations to Iuliana Bobanga, MD for winning first place oral presentation at the ACS Ohio Chapter meeting

April 18, 2014

Thanks to everyone's support and effort, the Huang Lab / UH / Rainbow Head Shaving Fundraiser for St. Baldrick's Foundation was a phenomenal success, raising more than $41,000 with 100+ heads shaved. Read a blog on St. Baldrick's Foundation website describing the involvement of Huang Lab's annual fundraising effort!

April 16, 2014

Congratulations to Dr. Scrimieri for winning the best oral presentation award at the annual Musculoskeletal Research Symposium. Way to go, Francesca!

April 14, 2014

The Huang Lab was recognized by the Alex's Lemonade Stand Foundation for being one of the top 100 fundraising team in 2013. Thanks to the effort of all members of the "Run, Alex! Run!" team during last September's Million Mile Run (MMR). The Huang Lab raised close to $10,000 in the month of September!


April 14, 2014

Congratulations to Dr. Agne Petrosiute for receiving the 2014-2015 Hyundai Hope-on-Wheels Hope Award in the amount of $250,000 (1/1/2015-12/31/2016). Official announcements will be made on September 23, 2014 at 10am at the UH Atrium.

April 2014

Latest publication from Huang Lab (Evans et al. Exp. Neurol. 2014; 254:109-120) was featured as the cover of the Journal's April 2014 issue. Congratulations, Teresa.

March 20, 2014

Congratulations to Dixon Dorand for receiving the Trainee Poster Award and the Minority Scientist Travel Award at the upcoming AAI meeting in Pittsburgh in May 2014.

March 17, 2014

Congratulations to Deb Barkauskas for successfully defending her PhD thesis. Congratulations, Dr. Barkauskas!

March 14, 2014

Members of the Huang Lab had yet another strong showing at this year's St. Baldrick's Head Shaving event held at the UH Rainbow Babies & Children's Hospital. Team Rainbow raised almost $25,000, and UH Rainbow site has raised more than $38,000 with more than 100 heads shaved. You can still donate to this great cause by visiting here: SBF Team Rainbow

February 12, 2014

Congratulations to Teresa Evans for successfully defending her PhD thesis. Congraulations, Dr. Evans!

February 6, 2014

Congratulations to Dr. Iuli Bobanga, MD for being selected as 1 of 10 best abstract submissions among more than a 1000 posters at this week's 2014 American Surgical Congress in San Diego, CA. She was chosen for oral presentation at this prestigious meeting. Way to go, Iuli!


February 4, 2014

Dr. Huang describes one of the projects funded by the Pediatric Cancer Research Foundation (PCRF).

December 3, 2013

The Huang lab hosted members of the Steven G. AYA Cancer Research Fund. We are so grateful for the generosity, support, and partnership of the Steven G. AYA Fund throughout this past year. Read the blog and support this worthy organization in our shared vision of curing childhood and adolescent cancer!

October 29, 2013

Congratulations to Jay for having his recent Stem Cell International article featured by BitPlane Inc. Read the article.

October 16, 2013

The Huang participated in the second Appreciative Inquiry project in partnership with the Weatherhead School of Management. Click to see the slideshow of the AI project. Click here to see the interactive slideshow of the first AI project held in the fall of 2012.

October, 2013

Congratulations to David Askew for winning the Poster Presentation Award at the 7th Annual Immunology Training Program Annual Retreat held at the Cleveland Clinic Lerner Research Institute on September 28, 2013.

October, 2013

Congratulations to Dixon Dorand who has just been named, "Bert & Iris Wolstein Research Scholar in Pediatric Oncology" with a funding support totaling $25,000.

October 4, 2013

The Huang Lab had a phenomenal month in partnering with Alex's Lemonade Stand Foundation to raise awareness for Childhood Cancer by participating in ALSF's Million Mile Run Initiative. Team "Run, Alex! Run" raised more than $9000 for childhood cancer research, and has collectively run or walked more than 900 miles! Great Job everyone! See the YouTube video featuring Jay Myers, Deb Barkauskas and Alex, along with countless other warriors around the country united for the same great cause!

September 30, 2013

The Huang Lab presented data as the lead-off speaker for the 21st Annual Cancer Immunotherapy Meeting during the 60th Anniversary of the Cancer Research Institute (CRI) at the Grand Hyatt in New York

September 24, 2013

The Huang Lab received 2013 Hyundai "Hope-on-Wheels" Hope Award at a ceremony at UH Atrium. Thanks to Hyundai for their support of Pediatric Cancer Research.

September 13, 2013

The Huang Lab is grateful to receive the support of the Steven G. AYA Cancer Research Fund. Read the article featuring Dr. David Askew and summer student, Robert Purgert.

September 10, 2013

Congratulations to Jay for being selected by the Midwest Blood Club to receive the best abstract / poster presentation award at their annual meeting to be held on September 19, 2013 in Cincinnati. Congratulations, Jay!

July 26, 2013

The Huang Lab has joined the great cause of "Go the Distance for Kids with Cancer!" by participating "the Million Mile Run (or Walk) in September" project sponsored by Alex's Lemonade Stand Foundation. Visit our participation website, sign up to join our team and raise funds and awareness for childhood cancer research! You caneither join the team and run/walk to raise funds, or donate to one of the team members... either way, you can be part of this great movement while getting yourself in shape! Visit our fundraising website for team "Run, Alex! Run!".

July 19, 2013

Congratulations to Dr. Agne Petrosiute, MD for being awarded a St. Baldrick's Fellowship Extension Award!Read the Announcement.

July 12, 2013

Congratulations to Dr. Iuliana Bobanga, MD for winning a poster presentation prize at the Case Comprehensive Cancer Center Retreat on July 12, 2013.

May, 2013

Congratulations to the following individual for receiving Summer Fellowship support:

Tim Welliver, Ph.D. - CWRU SOM student - St. Baldrick's Summer Fellow
Nathan Teich - CWRU SOM student - St. Baldrick's Summer Fellow
Robert Purgert - Miami University undergrad - Steven G. AYA Summer Fellow

May, 2013

Congratulations to Iuliana Bobanga, MD for winning first place at the annual meeting of the Ohio Chapter of American Surgical Society on May 3rd.

May, 2013

We are grateful to receive the support and partnership of The Littlest Heroes Vs. Cancer Foundation. Please check out their website and give them your full support!

April, 2013

The Huang lab has just received a 2-year, $250,000 grant from Hyundai "Hope-on-Wheels" Hope Award to study the role of Cdk's in ICN1-induced T-ALL. Hand print ceremony will occur in the Fall at the University Hospitals.
More details to come. Stay tuned.

April, 2013

Congratulations to Fred Allen for being awarded a Minority Scientist Travel Award at the upcoming American Association of Immunologists (AAI) Annual Meeting in Hawaii

March 31, 2013

Huang Lab and Team Rainbow Head Shaving Fundraising Effort on behalf of St. Baldrick's Foundation was featured on the Steven G. AYA Cancer Research Fund website.

March 18, 2013

A special ceremony took place in the Rainbow Performance Area on Monday morning as local event organizers, volunteers and shavees of the 2013 St. Baldrick's Foundation Fundraising Event Cleveland Chapter came together to celebrate and welcome Kathleen Ruddy, CEO of St. Baldrick's Foundation. Watch and read about this event as reported on Channel 5 News.

March 14, 2013

Member of the Huang Lab had another great showing this year at the annual St. Baldrick's Foundation Head Shaving Event at Rainbow Babies & Children's Hospital. Deb Barkauskas has de-throned Alex this year as the top fundraiser on Team Rainbow, and more money is pouring in. Please consider contributing to this most worthy cause in fueling research funding for Childhood Cancer Research. See Fox8 New coverage of this event.

February 26, 2013

Huang lab members have started the annual ritual of getting heads shaved to raise funds in support of St. Baldrick's Foundation, a terrific foundation which supports Pediatric Hematology-Oncology Research. Please check out Team Rainbow and support this worthy cause.

The Head-Shaving Date is Thursday, March 14th from 10:30am to 12:30pm in the Performance Area of Rainbow Babies & Children's Hospital.

January 26, 2013

Huang lab members were honored at the annual Steven G. AYA Research Fund fundraiser dinner. Drs. David Askew, Iuliana Bobanga, Agne Petrosiute, Alex Huang and Mrs. Deborah Barkauskas were in attendance to help support this worthy cause.

November 13, 2012

Dr. Huang spoke at the annual meeting of the Gabrielle's Angel Foundation in New York's Central Park Loeb Boathouse. Check out the video where Dr. Huang (0:52) and other speakers at the symposium spoke of the importance of the funding from GAF in supporting many of our ongoing research initiatives.

November 1, 2012

Congratulations to Dr. David Askew who was named the 2012 Recipient of the Steven G. AYA Cancer Research Scholarship. The entire Huang Lab is grateful for the support and partnership of the Steven G. AYA Cancer Research Fund! Read more about Dr. Askew's Award and please be sure to support the Steven G. AYA Cancer Researh Fund.  Thank you, Steven, Angie and Harry!

October, 2012

Congratulations to Dixon Dorand for being named recipient of the CWRU ITP T32 Training Grant Recipient for his study into antigen processing and presentation pathways of CNS Tumor-associated antigens. Congratulations Dixon.

 September 1, 2012

Congratulations to Fred Allen for receiving a two-year NIH NCI Diversity Supplement Grant to study intranodal immune cell migration in metastatic colon tumors. Congratulations, Fred!

September 12, 2012

Congratulations to Dr. Agne Petrosiute, who received the 2012 Hyundai Hope-on-Wheel Program Research Award in the amount of $75,000. Congratulations, Agne!

Watch local Cleveland Fox8 News and 19 Action News Coverage of the event and Agne's speech...

July 6, 2012
Read the latest press release regarding ALSF Innovator Award in Case Daily and WKYC

May 2012

We are fortunate to be visited by Harry and Angie Giallourakis from the Steven G AYA Cancer Research Fund on May 18th. We are so grateful for their passion and dedication to finding a cure for AYA cancer. Read the blog about the Huang Lab on their website.

May 2012

Huang Lab have just received a 2-year Innovation Award from the Alex's Lemonade Stand Foundation in the amount of $200,000. This grant is a collaborative project among Drs. Huang, Petrosiute and Dr. Nicole Steinmetz (BME, CWRU) aimed at enhancing immune surveillance in brain tumors.

Fracesca Scrimieri, Ph.D.
April 2012
Dr. Francesca Scrimieri just received appointment to the Orthopedic Department's T32 Training Program for her ongoing work in osteosarcoma.

March 2012
Member of the Huang Lab participated in the St. Baldrick's Foundation's annual head-shaving fundraising event as part of the Rainbow Babies & Children's Team. Team Rainbow had over 33 shaves, raising more than $27,000 (second top team in Cleveland). Dr. Huang raised $4900, placing him on top-ten list of individual fund-raisers from the City of Cleveland. To celebrate Cleveland's 10th anniversary in participating in this most worthy cause, Team Rainbow hosted its first-ever hair-shaving event in the Atrium of University Hospitals on March 9th.

September 2011
Deborah Sim Barkauskas
Deborah Barkauskas received appointment to the Biomedical Engineering Department's T32 Training Program for her ongoing work in CNS imaging.


August 2011Deborah Sim Barkauskas

Congratulations to Deborah Barkauskas for winning best poster presentation at the 2011 Annual International Microscopy & Microanalysis Meeting in Nashville, TN.

 July 2011Agne Petrosiute

Congratulations to Dr. Agne Petrosiute, MD for being awarded the FRAP Career Development Award. This $40,000 award is given to one senior fellow-junior faculty each year in the Department of Pediatrics in support and recognition of his/her accomplishment in research.

June 2011
Youmna Othman, M.D.
Congratulations to Youmna Othman, MD for being chosen as a recipient of the St. Baldrick's Fellow Scholarship through a competitive national grant review process for her proposal to monitor T cell ALL infiltration in the CNS through the Blood-Brain Barrier in a spontaneous murine leukemia model. This award is for a 2-year period in the amount exceeding $155,000.

June 2011

Dr. Alex Huang has received an additional $230,000 grant from the St. Baldrick's Foundation for the laboratory's effort to define immune surveillance in pediatric sarcomas and other cancers.

April 2011

Congratulations to Deborah Barkauskas for being named the 2011 Distinguished Scholar Award in the upcoming Microscopy & Microanalysis 2011 meeting in Nashville, TN for her paper entitled, Monitoring Immune Cell Infiltration in the Brain with Intravital Two-Photon Microscopy. She will receive compensation to attend the annual meeting in August, and will present her research finding in T cell recruitment in EAE as a poster.

March 2011

The Huang lab has another spectacular year of fund-raising on behalf of the St. Baldrick's Foundation. Dr. Huang, Jay Myers, and Jennifer Tsai were part of the Rainbow Babies & Children's Hospital Team which raised a record $23,000+. Dr. Huang was among the top 10 personal fundraisers in the city of Cleveland, with more than $4700.

March 2011

Congratulations to Jennifer Tsai, CWRU SOM for being named a St. Baldrick's Summer Fellow for her work in characterizing antigen presenting cell populations in the CNS of EAE mosue. The award is for a total of $5000 for one year.

Our lab / shipping address:


Wolstein Research Building, Room 6402

2103 Cornell Road

Cleveland, OH 44106-7288

(216) 368-0015


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2103 Cornell Road, Cleveland, OH 44106
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