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Huang Laboratory at Case Western Reserve University School of Medicine

Discovering Immunity in Health & Disease. Finding Cures for Childhood Cancer.

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About Alex Tong:


Alex is originally from Dallas, TX and attended Cistercian in Irving through secondary school. Thereafter, he matriculated at Rhodes College in Memphis, TN to pursue his B.S. in Biochemistry & Molecular Biology. As an undergraduate, Alex was a St. Jude Children's Research Hospital Summer Plus Fellow and subsequently a Pediatric Oncology Education Fellow in the Taosheng Chen Lab, where he studied nuclear hormone receptor protein-protein interactions and alveolar rhabdomyosarcoma oncoprotein regulation. At St. Jude, Alex fell in love with bench-to-bedside pediatric oncology research and was inspired to pursue MD-PhD training at Case Western Reserve to further his dream of developing novel cures for childhood cancers.

 

In the Huang Lab, Alex’s primary research interest is lymphocyte trafficking in physiological and inflammatory conditions, with a special focus on regulatory T cells (Tregs). He is studying this differential Treg trafficking using flow cytometry and intravital 2-photon laser scanning microscopy. He is also collaborating with lab colleagues to investigate cellular immunotherapies and tumor vaccines in mouse models.


In his increasingly diminishing spare time, Alex enjoys exploring the booming Cleveland food scene, attending Cleveland Orchestra concerts, playing in CaseMed’s Doc Opera Band, and ruminating on what does the fox say. He is also a volunteer violin teacher at the Joyful Noise Neighborhood Music School, a non-profit organization that provides free music lessons to children who cannot otherwise afford them.


Alex’s bio:

 

Education:

2007-2011 B.S. with Honors, summa cum laude, Department of Biochemistry and Molecular Biology, Rhodes College, Memphis, TN

2011-present M.D./Ph.D. candidate, Case Western Reserve University School of Medicine, Medical Scientist Training Program, Cleveland, OH

 

Professional Memberships:

2014-present American Association of Immunologists, Student Member

 

Awards & Honors:

2007 National Merit Finalist

2007-2011 Rhodes College Bellingrath Fellowship

2007-2011 Rhodes College Honor Roll

2010 Phi Beta Kappa

2011 Outstanding Achievement Award in Biochemistry and Molecular Biology, Rhodes College

2011 Rhodes College Hall of Fame

2014 First Place Poster Award, 37th Annual Biomedical Graduate Student Symposium, Case Western Reserve University

2014 Poster Award, 8th Annual Immunology Training Program Retreat, Case Western Reserve University

2014 Best Poster Award, APSA Midwest Regional Meeting, Cleveland, OH

2015 Best Presentation Award, Department of Pathology Annual Retreat, CWRU, Cleveland, OH

 

Graduate School Research Rotations:

2011 Alex Y. Huang, M.D., Ph.D., Associate Professor, Department of Pediatrics, Case Western Reserve University, Cleveland, OH

2012 Shigemi Matsuyama, D.V.M., Ph.D., Associate Professor, Department of Medicine, Case Western Reserve University, Cleveland, OH

2012 Robert Fairchild, Ph.D., Staff, Department of Immunology, Cleveland Clinic Lerner Research Institute, Cleveland, OH

 

Publications:

1. Pondugula SR, Tong AA, Wu J, Cui J, Chen T. Protein phosphatase 2Cbetal regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. Drug Metab Dispos. 2010 Sep;38(9):1411-6.

2. Allen F^, Tong AA^, Huang AY. Unique transcompartmental bridge: antigen-presenting cells sampling across endothelial and mucosal barriers. Frontiers in Immunology 2016. 7:231. doi: 10.3369/fimmu.2016.00231 (^co-first author)

3. Metheny L, Eid S, Lingas K, Reese J, Meyerson H, Tong A, de Lima M, Huang AY. Intra-osseous co-transplantation of CD34-selected umbilical cord blood and mesenchymal stromal cells. Hematology & Medical Oncology 2016. 1(1): 41-45.

 

Oral & Poster Presentations:

1.Tong A, Pondugula S, Chen T. A phosphomimetic mutation at threonine-40 abolishes transactivation activity of human vitamin D receptor in HepG2 liver carcinoma cells. Poster presented at: Undergraduate Research and Creative Activity Symposium; 2009 May 1; Rhodes College, Memphis, TN.

2.Tong A, Pondugula S, Chen T. Protein phosphatase 2Cβl regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. Oral presentation at: Undergraduate Research and Creative Activity Symposium; 2010 April 30; Rhodes College, Memphis, TN.

3.Tong A, Liu L, Chen T. Elucidating the role of glycogen synthase kinase 3 beta in regulating the function of PAX3-FOXO1 by phosphorylation. Oral presentation at: Undergraduate Research and Creative Activity Symposium; 2011 April 29; Rhodes College, Memphis, TN.

4.Tong A, Allen F, Huang AY.  Regulatory T cell trafficking in peripheral lymph nodes. Poster presented at: MSTP Winter Retreat; 2014 Mar 4; Case Western Reserve University, Cleveland, OH.

5.Tong A, Allen F, Huang AY. Regulatory T cell trafficking in peripheral lymph nodes. Poster presented at: Research ShowCASE; 2014 Apr 18; Case Western Reserve University, Cleveland, OH.

6. Huang AY, Scrimieri F, Tong A, Askew D, Eid S, Bobanga I, Corn D.VCAM-1 enhances immune evasion in a murine model of metastatic cervical cancer. Poster presented at: Cancer Immunobiology Poster Session. 101st Annual American Association of Immunologists Meeting; 2014 May 5; Pittsburgh, PA.

7.Tong A, Allen F, Huang AY. Regulatory T cell trafficking in peripheral lymph nodes. Poster presented at: 37th Annual Biomedical Graduate Student Symposium; 2014 May 9; Case Western Reserve University, Cleveland, OH.

8.Tong A, Allen F, Huang AY. Regulatory T cell trafficking in peripheral lymph nodes. Poster presented at: 8th Annual Immunology Training Program Retreat; 2014 Sep 26; Case Western Reserve University, Cleveland, OH.

9.Tong A, Allen F, Huang AY. Regulatory T cell trafficking in peripheral lymph nodes. Poster presented at: APSA Midwest Regional Meeting; 2014 Nov 15; Case Western Reserve University, Cleveland, OH.